>>Hello everybody. I am Toshihiko Nishimura from Stanford. University is there to TTT out here, super aging, global OMIM global transportation group about infections, uh, or major point of concerns. In addition, this year, we have the COVID-19 pandemic. As you can see here, while the why the new COVID-19 patients are still increasing, meanwhile, case count per day in the United state, uh, beginning to decrease this pandemic has changed our daily life to digital transformation. Even today, the micro segmentation is being conducted online and doctor and the nurse care, uh, now increase to telemedicine. Likewise, the drug development process is in need of major change paradigm shift, especially in vaccine in drug development for COVID-19 is, should be safe, effective, and faster >>In the >>Anastasia department, which is the biggest department in school of medicine. We have Stanford, a love for drug device development, regulatory science. So cold. Say the DDT RDS chairman is Ron Paul and this love leaderships are long mysel and stable shaper. In the drug development. We have three major pains, one exceedingly long duration that just 20 years huge budget, very low success rate general overview in the drug development. There are Discoverly but clinical clinical stage, as you see here, Tang. Yes. In clinical stage where we sit, say, what are the programs in D D D R S in each stages or mix program? Single cell programs, big data machine learning, deep learning, AI mathematics, statistics programs, humanized animal, the program SNS program engineering program. And we have annual symposium. Today's the, my talk, I do like to explain limitation of my science significance of humanized. My science out of separate out a program. I focused on humanized program. I believe this program is potent game changer for drug development mouse. When we think of animal experiment, many people think of immediately mouse. We have more than 30 kinds of inbred while the type such as chief 57, black KK yarrow, barber C white and so on using QA QC defined. Why did the type mice 18 of them gave him only one intervention using mouse, genomics analyzed, computational genetics. And then we succeeded to pick up fish one single gene in a week. >>We have another category of gene manipulated, mice transgenic, no clout, no Kamal's group. So far registered 40,000 kind as over today. Pretty critical requirement. Wrong FDA PMDA negative three sites are based on arteries. Two kinds of animal models, showing safety efficacy, combination of two animals and motel our mouse and the swine mouse and non-human primate. And so on mouse. Oh, Barry popular. Why? Because mouse are small enough, easy to handle big database we had and cost effective. However, it calls that low success rate. Why >>It, this issue speculation, low success rate came from a gap between preclinical the POC and the POC couldn't stay. Father divided into phase one. Phase two has the city FDA unsolved to our question. Speculation in nature biology using 7,372 new submissions, they found a 68 significant cradle out crazy too, to study approved by the process. And in total 90 per cent Radia in the clinical stages. What we can surmise from this study, FDA confirmed is that the big discrepancy between POC and clinical POC in another ward, any amount of data well, Ms. Representative for human, this nature bio report impacted our work significantly. >>What is a solution for this discrepancy? FDA standards require the people data from two species. One species is usually mice, but if the reported 90% in a preclinical data, then huge discrepancy between pretty critical POC in clinical POC. Our interpretation is data from mice, sometime representative, actually mice, and the humor of different especially immune system and the diva mice liver enzyme are missing, which human Liba has. This is one huge issue to be taught to overcome this problem. We started humanized mice program. What kind of human animals? We created one humanized, immune mice. The other is human eyes, DBA, mice. What is the definition of a humanized mice? They should have human gene or human cells or human tissues or human organs. Well, let me share one preclinical stages. Example of a humanized mouse that is polio receptor mice. This problem led by who was my mentor? Polio virus. Well, polio virus vaccine usually required no human primate to test in 13 years, collaboration with the FDA w H O polio eradication program. Finally FDA well as w H O R Purdue due to the place no human primate test to transgenic PVL. This is three. Our principle led by loss around the botch >>To move before this humanized mouse program, we need two other bonds donut outside your science, as well as the CPN mouse science >>human hormone, like GM CSF, Whoah, GCSF producing or human cytokine. those producing emoji mice are required in the long run. Two maintain human cells in their body under generation here, South the generation here, Dr. already created more than 100 kinds based on Z. The 100 kinds of Noe mice, we succeeded to create the human immune mice led the blood. The cell quite about the cell platelets are beautifully constituted in an mice, human and rebar MAs also succeeded to create using deparent human base. We have AGN diva, humanized mouse, American African human nine-thirty by mice co-case kitchen, humanized mice. These are Hennessy humanized, the immune and rebar model. On the other hand, we created disease rebar human either must to one example, congenital Liba disease, our guidance Schindel on patient model. >>The other model, we have infectious DDS and Waddell council Modell and GVH Modell. And so on creature stage or phase can a human itemize apply. Our objective is any stage. Any phase would be to, to propose. We propose experiment, pose a compound, which showed a huge discrepancy between. If Y you show the huge discrepancy, if Y is lucrative analog and the potent anti hepatitis B candidate in that predict clinical stage, it didn't show any toxicity in mice got dark and no human primate. On the other hand, weighing into clinical stage and crazy to October 15, salvage, five of people died and other 10 the show to very severe condition. >>Is that the reason why Nicole traditional the mice model is that throughout this, another mice Modell did not predict this severe side outcome. Why Zack humanized mouse, the Debar Modell demonstrate itself? Yes. Within few days that chemistry data and the puzzle physiology data phase two and phase the city requires huge number of a human subject. For example, COVID-19 vaccine development by Pfizer, AstraZeneca Moderna today, they are sample size are Southeast thousand vaccine development for COVID-19. She Novak UConn in China books for the us Erica Jones on the Johnson in unite United Kingdom. Well, there are now no box us Osaka Osaka, university hundred Japan. They are already in phase two industry discovery and predict clinical and regulatory stage foster in-app. However, clinical stage is a studious role because that phases required hugely number or the human subject 9,000 to 30,000. Even my conclusion, a humanized mouse model shortens the duration of drug development humanize, and most Isabel, uh, can be increase the success rate of drug development. Thank you for Ron Paul and to Steven YALI pelt at Stanford and and his team and or other colleagues. Thank you for listening.

you live from Orlando Florida it's the cube coverage conf 18 got to you by Splunk welcome back to comp 2018 this is the cube the leader in live tech coverage my name is Dave Volante I'm here with my co-host Stu minimun we're gonna start the day we're going to talk to some customers we love that John Morris here is the MIS program director at UConn the Huskies welcome to the cube good to see you and he's joined by Ryan O'Connor who's the senior advisory engineer at Splunk he's got the cool hat on gents welcome to the cube great to have you thank you thank you for having us so kind of a cool setting this morning is the Stu's first conf and I said you know when you see this it's kind of crazy we're all shaking our phones we had the horse race this morning we won so that was kind of orange yeah team are and team orange as well that's great you're on Team Orange so we're in the media section and the median guys were like sitting on their hands but Stu and I were getting into it good job nice and easy so Jon let's start with you start always left to start with the customer perspective maybe you describe your role and we'll get into it sure so as you mentioned I'm the director of our undergrad program Mis management information systems business technology we're in the school of business under the operations and information management department the acronym OPI M okay cool and gesture Ryan tell us about your role explain the Hat absolutely yeah so I'm a member of an honorary member of the Splunk trust now I recently joined Splunk about a month ago back in August and yeah and outside of my full-time job working at Splunk I'm also an adjunct professor at the University of Connecticut and so I helped John in teaching and you know that's that's kind of my role and where our worlds sort of meet so John we were to when I were talking about the sort of evolution of Splunk the company that was just you know okay log file analysis kind of on-prem perpetual license model and it's really evolved and its permanent permeating throughout you know many organizations but maybe you could take us through sort of the early days and it was UConn for a while what what was life like before Splunk what prompted you to start playing around with Splunk and where have you taken it what's your journey look like so about three years ago we started looking at it through kind of an educational lens started to think of how could we tie it into the curriculum we started talking to a lot of the recruiters and companies that many of our students go into saying what skillsets are you looking for and Splunk was definitely one of those so academia takes a while to change the curriculum make that pendulum swing so it was how can we get this into students hands as quickly as possible and also make it applicable so we developed this initiative in our department called OPI M innovate which was all based around bringing emerging technology skills to students outside of the general curriculum we built an innovation space a research lab and really focused in bringing students in classes and incorporating it that way we started kind of slowly different parts of some early classes about three years ago different data analytics predictive analytics courses and then that really built into we did a few workshops with our innovate initiative which Ryan taught and then from there it kind of exploded we started doing projects and our latest one was with the Splunk mobile team okay you guys had some hard news around now well today right yeah maybe take us through that absolutely wanted sure yeah I'll take that so we we teach a course on IOT industrial IOT at the University of Connecticut and so we heard about the mobile projects and you know the basically they were doing a beta of the mobile and application so we we partnered with them this summer and they came in you know we have a Splunk Enterprise license through Splunk for good so we're able to actually ingest Splunk data and so as part of that course we can ingest IOT data and use Splunk mobile to visualize it all right right right maybe you could explain to our audience that might not know spun for good absolutely yeah so spun for good is a great initiative they offer a Splunk pledge license they call it to higher education institutions and research initiatives so we're able to have a 10 gig license for free that we can you know run our own Splunk enterprise we can have students actually get hands-on experience with it and in addition to that they also get free training so they can take Splunk fundamentals one and two and actually come out of school with hands-on experience and certifications when they go into the job market that's John name you know we talk so much about them the important role of data and you know that the tools change a lot you know when we talk about kind of the next generation of jobs you're right at that intersection maybe you can give you know what what are what are the students what are they looking for what are the people that are looking for them hoping that they come out of school with you know yeah it's it's um you have two different types of students I would say those that know what they're looking for and those that don't that I really have the curiosity they want to learn and so we we try to build this initiative around both those that maybe they're afraid of the technology and the skills so how do we bring them in how do we make a very immersive environment kind of have that aha moment quickly so we have a series of services around that we have what's called tech kits the students come in they're able to do something applicable right away and it sparks an interest and then we also kind of developed another path for those that were more interested in doing projects or they had that higher level skill set but we also wanted to cultivate an environment where they could learn more so a lot of it is being able to scaffold the learning environment based off of the different student coming in so it's interesting my son's a junior in college at GW and he's very excited he's playing around with date he says I'm learning are I'm learning Tablo I'm like great what about Splunk and he said what's that yes so yeah then though it's a little off-center from some of the more traditional visualization tools for example so it's it's interesting and impressive that you guys sort of identified that need and actually brought it to two students how did that all how what was in an epiphany or was that demand from the students how'd that come about it was a combination of a lot of things you know we were lucky Ryan and I have known each other for a long time as the director of the program trying to figure out what classes we should bring in how to build out the curriculum and we have our core classes but then we have the liberty to build out special topics things that we think are irrelevant up-and-coming we can try it out once if it's good maybe teach it a few more times maybe it becomes a permanent class and that's kind of where we were able to pull Ryan in and he had been doing consulting for Splunk for a number of years I said I think you know this is our important skill set is it something that you could help bring to the students sure yeah yeah I mean one of the big courses we looked at was a data analytics course and we were already teaching with a separate piece of software not gonna name names but essentially I looked at it one for one like what key benefits does this piece of software have you know what are the students trying to get out of it and then just compared to one for one to Splunk like could Splunk actually give them the same learning components and all that and it could and and with this one for swum for a good license and all that stuff we could give them the hands-on experience and augment our teaching with that free training so and they come out of school they have something tangible they can say you know I have this and so that would kind of snowball once that course worked then we could integrate it into multiple other courses so you were able to essentially replicate the value to the students of the legacy software and but also have a modern platform exactly exactly yep yeah you know that and that was a what was like a Doug was talking about making jokes about MDM and codifying business processes and yeah it's a little bit more of an antiquated piece of software essentially you know and I mean it was nice it did a great job but there wasn't when we were talking to recruiters and stuff it wasn't a piece of software that recruiters were actually looking at so we said we were hearing Splunk over and over again so why not just bring it into the classroom and give them that so in the keynote this morning started to give a vision I believe they call it Splunk next and mobile things like augmented reality are fitting in you know how do you look at things like this what what how's the mobile going to impact you especially I would think yeah so when we kind of came up with our initiative we identified five tracks that both skill sets we believe the students needed and that and companies were kind of looking for a lot of that was our students would go into internships and say hey you know the the set skills that were learning you know they're asking us to do all this other work in AWS and drones and VR so as again it's part of this it was identifying let's start small five tracks so we started with 3d printing virtual reality microcontrollers IOT and then analytics kind of tying that all together so we had already been building an environment to try and incorporate that and when we kind of started working with the spunk mobile team there's all these different components we wanted to not only tie into the class but tied into the larger initiative so the goal of the class is not to just get these students the skills interesting interested in it but to spread that awareness the Augmented part is just kind of another feature was the next piece that we're looking in to build activities and it just had this great synergy of coming in at the right time saying hey look at this sensor that we built and now you can look at data in an AR it's a really powerful thing to most people so yeah they showed that screenshot of AR during the keynote and one of the challenges that we have at the farm so we're teaching that this is the latest course that we're talking about on an industrial IOT one of the challenges we have at that farm is we don't have a desk we don't have a laptop but we do have a phone in our pocket and we have we can put a QR code or NFC tag anywhere inside that facility so we can actually have we have students go around and you know they can put an iPhone upto a sensor or scan a QR code and see actual live real-time data of what those sensors are doing which is it's an invaluable tool inside the classroom and in an environment like that for sure so it's interesting able to do things we never would have been able to do before I want to ask you about come back to mobile yeah as you you just saying it was a something that people have wanted for a long time it took a while yeah presumably it's not trivial to take all this data and present it in a format and mobile that's simple number one and number two is a lot of spunky users are you know they're at the command center right and they're on the grid yep so maybe that worked to your advantage a little bit and that you know you look at how quickly mobile apps become obsolete hmm so is that why it took so long because it was so complicated and you had a user profile that was largely stationary yeah and how is that change yes honestly I'm not sure in the full history of the mobile app I know there previously was a new mobile app and I are there was an old mobile app and this new one though is you use it the new one yes oh so when we're talking about augmented reality that might be we may not been clear on that augmented reality is actually part of its features and then in addition we have the Apple TV app is in our lab we have a dashboard displayed on a monitor so not only can we teach this class and have students setting up sensors and all this but we can live display it for everyone to come in and look at all the time and we know that it's a secure connection to our back-end people walk into the lab and the first thing I see is this live dashboard Splunk data from the Apple TV based off of project we've been working on what's that well that's a live feed from a farm five miles off campus giving us all these data points and it's just a talking point people are like wow how did you do that and you know it kind of goes from there yeah and the farm managers are actively looking at it too so they can see when the doors are open and closed to the facility you know the temperature gets too high all these metrics are actually used by the you know that was the important part to actually solve a business problem for them you know we we built a proof of concept for the class so the students could see it then their students are kind of replicating another final project in the class class is still ongoing but where they have to build out a sensor for for plants to so it's kind of the same type of sensor kit but it's they're more stationary plant systems and then they have to figure out how to take that data put it into Splunk and make sense of it so there's all these different components and you get for the students get the glam factor you can put it in a fishbowl have the Apple TV up there exactly and that's I mean part of it when we when we started to think about in ishutin you know it was recruitment you know how do we get students beyond that fear of technology especially kind of coming into a business school but it really went well beyond that we aligned it with the launch of our analytics minor which was open to anyone so now we're getting students from outside the school a bit liberal arts students creating very diverse teams and even in the class itself we have engineers business psychology student history student that are all looking to understand data and platforms to be able to make decisions so there's essentially one Splunk class today instead of a Splunk 101 there this semester there's there's a couple classes that are actually using Splunk inside the classroom and I mean depends on the semester how many we have going on that are actually there's three the semester I sorry I misspoke there we have a another professor as well who's also utilizing it so so yeah we have three three classes that are essentially relying on Splunk to teach different components or you know is it helped us understand is it part of almost exclusively part of the analytics you know curriculum or is it sort of permeate into other Mis and computer science or right now it's within our kind of Mis purview trying to you know build all their partners within the university and the classes they're not it's not solely on spunk spunk is a component of you the tool so it's like for example the particular industrial IOT course it is understanding microcontrollers understanding aquaponics and sustainability understanding how to look at data clean data and then using Splunk as a tool to help bring that all together yeah it's kind of the backbone you know love it and then and I mean in addition to I just wanted to mention that we've had students already go out into the field which is great and come back and tell us hey we went out to a job and we mentioned that we knew Splunk and we were you know a shoo-in for certain things once it goes up on their LinkedIn profile and start getting yeah I mean I again I would think it's right up there with I mean even even more so I mean everybody says and right and our day it was SPSS now it's our yep tableau obviously for the VIS everybody's kind of playing around but spunk is a very you know specific capability that not everybody has except every IT department on the planet exactly coming out of school you take a little bit deeper you either you find you find that out yeah cool well great work guys really thank you guys coming on the cube it was great to meet you I appreciate it incoming all right you're welcome all right keep it right - everybody stew and I will be right back after this this is day one of cough 18 from Splunk this is the cube [Music]