>>from around the globe. It's the queue with digital coverage of AWS Public sector online brought to you by Amazon Web services. Welcome back. I'm stew minimum. And this is the Cube coverage of Amazon Web service Public sectors, online summit Always love. We have phenomenal practitioner discussion. Of course, public sector includes both government agencies, universities, education, broad swath, you know, inside that ecosystem and some really, you know, important and timely discussion we're having. Of course, with the global pandemic Kobe 19 happening. I'm really happy to welcome to the program Wei Li, who is a PhD and principal investigator as well as an assistant professor both Children National Research Institute associated with George Washington University way Thank you so much for joining us. >>Yeah. Thank you for the opportunity. We're here. >>Alright. Why don't we start with Ah, give us a little bit of you know, your research focus in general. And you know what projects it is that you're working on these days? Yeah, >>sure. So, yeah, so hello, everyone. So our laboratory is many interested in using computational biology and jim editing approaches to understand human genome and human disease. And we're particularly interesting in one gene editing technology will be called CRISPR screening. So this is a fascinating, high for proven technology because it tells you whether one doctor 20,000 human genes are connected with some certain pieces fit in type in one single experiment. So in the possibly developed some of the widely used every reasons to analyze the swimming data has been downloaded off by over 60,000 times. So it's really popular, and right now there are a couple of going projects. But basically we are trying to, for example, problem in machine learning and data mining approaches to find new clues of human disease from the original mix and screening big data on. We also collaborated with a lot of blacks around the world and to use this technology to use this technology to find new cures and drugs for cancer and other decisions. So this is the basic all the way off our current research programmes. Interns off the Conradi 19 research. I think one of the major projects we are having is that, um, we noticed that Christmas winning and other similar screening methods has been widely used in many years. Many research adapted to study waters infection. So in the past 10 years we have seen people you are using their Christmas screening and our AI suite, for example, to study HIV is a car wires, best bars, Western ire virus, Ebola influencers and also coronavirus. So that raises an interesting question from us if we collect all the screening data together. But these viruses, what a new information can we find that we cannot identify for the single study, for example, coe and identify new patterns or new human genes that are that are common in responsible for many different viruses? Type of all, we can find some genes that I work only for some certain people viruses so more well, we know that there are a lot of drugs that target different genes, and we are particularly interested in, for example, can repurpose some of these drugs to treat different hyper viruses, including Kobe, 18 19. So that's the one of the major profits off ongoing research, right and left ready to call the idea, writing So India. And we hope that we can find some new new Jim functions that after that that are broader, really essential for different hyper viruses. I also new drug targets that can potentially treat existing a new drug existing and new viruses, including compared to 19 >>Yeah, crisper. Shown a lot of promise is definitely a lot of excitement in the research community to be ableto work on this. You talked a little bit about, you know, big data, obviously a lot of computational power required to do some of the things you're talking about. Can you speak a little bit to the partnership between computer science and the medicine? How do you make sure on that? You know, there's that marrying of, you know, the people in the technology focus in the medical space. >>Yeah, so I think, Yeah, my my research background is actually from computer science. I call her on the grand graduates from their committed size. So I know a lot about some of the signs and have arisen. But right now it's quite interesting because our research for focus half on computer science and half on their medicine. So it's a complete heart experience, but it's really super was a super exciting to connect both women in science and medicine together. So I think most of the time we are focusing on the coding and the average analysis on. But at the same time, we also spent a lot of time like interpreting the results. In essence, we need a lot off. Yeah, knowledge from biology and medicine to make sense, to make our results since and interpret double in the end, we hope that our results can be They went into a son, for example, canonical, actionable solutions, including new drugs. >>Yeah, it's if you think about you know, the research space. You know, often you know its projects that you're taking months or years to investigate things for talking about the current code 19 pandemic. Of course, there's a critical need today for fast moving activities. So you know what? What are the outcomes from the cover? 19 aspects of of what you're working on. What are some of the outcomes that we might be able to help patients survivability and other things regarding, You know, this specific disease? >>Yeah, So I think there are two major are I would say there are two major benefits from their outcome of our research project. So the first the first thing is that we hope to find some genes that have that can be potentially drug targets. So if they are existing drug second heavily genes, then that would be perfect because we don't need to do anything. Apologies. We just need to try that. Extend existing drugs Toe cabinet is James and in the end, we hope that these drugs can have the broad on the wire. I would say the broad answer. Borrow activity. That means that and you leave, for example, if these drugs can be potentially used to treat Cooley 19 and sometimes in in several years later in the future if there's a new virus coming out. Hopefully they were doing like they're it's already the drugs that target known Gene. Hopefully, that's there were assume the noon numerous that never happened in something the future. But I hope that when the new risk is coming, we already have the new drugs to track it this way. Already have existing drugs to target these viruses, so that's one part and the alibis that way. We have, like, spend a lot of kind of, for example, collecting the genomics and screening data, and we are hoping that our research results can be freely accessible around the road by many different researchers in different laps. So that's why we are rely on AWS to build up there to process and to analyze the data as well as to, uh, to build up an integrated database and websites such that are the outcomes off our projects can be freely accessible around the world. Many other researchers. >>Yeah, great. I'm glad you connected the dots for us. For aws can you speak a little bit too? Obviously, Cloud has, you know, the ability for us to use, you know, nearly infinite computational capabilities. What's specific about AWS helps you along that project. Uh, let's start there. >>Yeah, So I think our AWS really helps us a lot because we developed on average and process their screening data actually takes, like, two or three days to Christmas one data. But if you were talking about, like, tens or hundreds or even thousands off the screen data existing, the high high performance cross team doesn't really help because it takes maybe years to finish. AWS provides, like flexible computing resources, especially the easy two instance that we can quickly deploy and process in military short amount of time. So our estimation is that we can reduce the amount of Time Media 2% to process the poverty Christmas. We need data from months to just a few days. So that's one part and the other guys that we are trying to build up the website and database, as I mentioned before, with which we host a large amount of data. And I think in that sense, AWS and the commuting instance as well as the AWS RDS service really helped us a lot because we don't need to worry too much about. There's a lot of the details of the after deployment off their database and the website. We just go ahead and use that as a service is really straightforward and save us a lot of kind of effort. >>Yeah, and you talk about the sharing of data. Information is so important, But of course it would, talking about medical data highly regulated. So you know what's important to the cloud to make sure that you can share with all the other researchers yet still make sure that there is the security and compliance that is required? >>Yeah, so yeah, that's a really good question. So right now, we don't really need to do if the patient information because all the data we get this from the public domain, it's It's both on the human sound lines, not on human patients. So we don't have their concerns about the privacy protections at this moment. But I think in the future, if you want to integrate genomics state our reach, this screen indeed A, which is already in my research plan. I think the highly secure AWS system actually really provided a really nice for us to do this job. >>Can you give us a little bit? Look forward as to where do you see this research going? What applicability is there before? What you're doing now? Both. You know, as this current pandemic plays out as well as applicability beyond Corp in 19. >>Yeah, sure, I think I think one of their major focus off our current, The company in 19 project is that we hope to find some drug targets tohave the broader under fire activity. So I think in the future, if they knew where it's coming out of the estimated locally in the 19 we hope that we are well prepared for that. I think in the future they're sharing as well as collateral cloud computing. You'll be becoming more and more important as you can see that most of us are working from home right now. So it's really critical to require us to have the platform toe accelerate accelerating sharing between research labs and around the world. And I think many different. I think aws provides this really nice preference for us to do this job well. >>Wei Li, thank you so much for sharing with our audience your updates, really important work. We wish your team the best of luck and hope that you also stay safe. >>Yeah, thank you so much. >>Alright, Stay with us for more coverage from AWS Public sector Summit online. I'm stew Minimum And thanks as always for watching the Cube >>Yeah, yeah, yeah, yeah, yeah